Endocrine Abstracts

Introduction: Nuclear medicine procedures offer a possibility of tracing tumor cells based on their physiology. Gastrin-Releasing Peptide receptor (GRPr) is aberrantly expressed in numerous cancers, among them prostate cancer. Demobesin-15 ([99mTc]DB15) is a novel GRPR-antagonist designed for the evaluation of GRPr expression in different tumors. It has been shown to accumulate in animal prostate cancer models. Hereby, we present our experiences with the first in-hu...

Context: Prolactin (PRL) exerts a crucial role in the regulation of mammalian reproduction and in the promotion of lactation as response to the suckling reflex. Beyond this, it directly modulates gluco-insulinemic metabolism.ObjectiveTo dissect glucose metabolism during and after pregnancy in patients with chronic hyperprolactinemia (CTPE).MethodsThis longitudinal study included 52 reproductive aged women with CTPE due to pituitary adenomas (43 microadenomas, 9 macroadenomas),...

Purpose: The present study aimed at investigating the morphology and function of reproductive system in women with hyperprolactinemia (HPRL) receiving chronic treatment with cabergoline (CAB)Methods: Twenty-three women(aged 34.21±10.09 yrs) with HPRL, including 17 with microprolactinoma, 3 with macroprolactinoma and 3 with iatrogenic HPRL, entered the study. All patients were well-controlled with CAB treatment (medium dose 0.46±0.45 mg/week). In po...

Introduction: AVP secretion disturbances in pituitary lesions usuall, present as AVP deficienc, due to compression of the posterior pituitary lobe. Excessive secretion of AVP (syndrome of inappropriate antidiuresis) (SIAD) is ver, uncommon in patients with pituitary tumor. A few cases of non-functionating adenoma, prolactinoma, and even pituitary apoplex, were described to present with SIAD. Pituicytoma is a rare tumor of the neurohypophysis. The, usuall, present with visual d...

Rationale: The gluco-metabolic changes during pregnancy significantly impact women’s sexual behavior. This study aimed to define the relationship between metabolic health and sexual function, along with human circadian rhythms and sleep quality during pregnancy.Methods: This study included 57 pregnant women (14 evaluated at first trimester, G1; 18 at second trimester, G2, and 25 at third trimester, G3). Among groups, no difference between age, gesta...

The current study evaluated the impact of metabolic and hormonal alterations on sexual and psychological function in women with Polycystic Ovary Syndrome (PCOS). Fifty consecutive women aged 24.16±5.97 years with a diagnosis of PCOS were recruited; metabolic and hormonal parameters were measured and questionnaires related to sexual function (Female Sexual Function Index-FSFI) and psychological traits (Middlesex Hospital Questionnaire-MHQ, Body Uneasiness Test A and B-BUT A ...

Introduction: Gain of function mutations of RET protooncogene are associated with hereditary medullary thyrpoid cancer. There are mainly specific hot-spot RET gene mutations however they may differ between population.Aim of the study: In this study we report the prevalence of RET mutations in Polish population based on 20 years of experience of referral polish centers.Material and methods: RET ge...

Campania Region has been facing waste management crisis since 1980, characterized by urban, toxic and industrial waste illegal disposal, burying and incineration. Cadmium (Cd) is consistently shown to affect male reproductive function by multiple mechanisms, mostly elucidated in experimental models. The aim of the current single-center, observational, cross-sectional cohort study was to evaluate the prevalence of testis morphostructural alterations in a large cohort of men liv...

Background: Oxytocin (OXT) enhances glucose uptake and lipid utilization in adipose tissue and skeletal muscle.Dysfunction of the OXT system could underlie the pathogenesis of weight gain. Men and women with obesity were reported to have higher OXT blood levels compared to normal weight subjects. In contrast, metabolic syndrome has been associated with reduced fasting serum oxytocin in larger scale mixed gender studies.Aim: Data regarding the oxytocin sy...

Background: Reduced growth hormone (GH) secretory capacity is common in patients with obesity and metabolic derangements. The prevalence of GH deficiency (GHD) in this population is difficult to establish. Magnetic Resonance Imaging (MRI) pituitary findings may reflect specific endocrine alterations, as for GHD which is associated with lower pituitary height and volume (PV).Purpose: Our aim was to identify the pituitary morphological alterations predicti...